Here’s how to get Unique items in Diablo 4:

1.Clear the Cathedral of Light Capstone Dungeon on world tier two.
2.Select the third or fourth world tier difficulty.
3.Defeat bosses throughout Sanctuary.
3.Repeat until a Unique item drops.

Unique items will only drop on the Nightmare and Torment world tiers, which unlock after you beat the campaign on either the Adventure or Veteran tiers. Then, you must then clear the Cathedral of Light Capstone Dungeon in Kyovashad on the Veteran tier. This dungeon is recommended for characters above level 50, so it takes a while to get to the point where Unique items will begin to  Diablo 4 items drop for you.

On Nightmare and Torment, boss fights and special enemy encounters will have a small chance to drop a Unique item. In true Diablo fashion, they are designed for you to grind for, likely requiring you to defeat them over and over to loot it. The Butcher, for instance, has a low chance to drop The Butcher’s Cleaver. Furthermore, The Butcher appears randomly in dungeons, making it a difficult item to obtain.

Expect most bosses during the main quest to have a Unique item tied to them, especially the bosses at the end of each Act, such as Lilith’s Lament, and possibly end-game Nightmare Dungeons. Do note that this early in the game’s lifespan, we do not know if there are other methods to obtain Unique items, but we will update here if we discover them.

All Diablo 4 Unique items
Below is our ever-expanding list of Unique item locations in Diablo 4. All of the Unique items in the game were datamined by the Diablo 4 Database during the beta, thus they’re subject to change or may not feature right now. Until we confirm otherwise, Unique items yet to buy Diablo 4 items  be found in-game will be labeled unconfirmed. For brevity’s sake, we’ve only included the Unique affix and its effect for the unconfirmed items.